Cortex, Subcortex, Vasogenic Edema, and Cytotoxic Edema
Localize cortical and subcortical abnormality, then distinguish vasogenic from cytotoxic edema using diffusion, distribution, and mass effect.

In a brain edema report, location and diffusion behavior provide more information than T2/FLAIR hyperintensity alone. Vasogenic edema often predominates in white matter and relatively spares cortex. Cytotoxic edema reflects cellular swelling, can affect gray and white matter, and shows restricted diffusion at the appropriate stage.
The distinction is not absolute. Tumor, posterior reversible encephalopathy, venous disease, infection, and trauma can produce mixed patterns. DWI hyperintensity should be confirmed by low ADC to exclude T2 shine-through.
Assessment framework
- Locate the center of abnormality in cortical ribbon, subcortical white matter, or deep structures.