Amyloid-Related Imaging Abnormalities in Anti-Amyloid Therapy
A practical radiology review of Amyloid-Related Imaging Abnormalities in Anti-Amyloid Therapy, focused on imaging findings, differential diagnosis, reporting points, and...
RadPhrases Editorial Team2 min read
A practical radiology review of Amyloid-Related Imaging Abnormalities in Anti-Amyloid Therapy, focused on imaging findings, differential diagnosis, reporting points, and high-yield teaching pearls.
- in Alzheimer Disease treated with anti-Aβ monoclonal antibodies
Big Picture
- Anti-amyloid monoclonal antibodies (MABs) (aducanumab, lecanemab, etc.) ↓ amyloid plaques
- Main imaging complication = ARIA
- MRI = only modality to diagnose & monitor ARIA → radiologist is
- What is ARIA?
- Two main types
ARIA-E (Edema / Effusion)
- Vasogenic edema ± sulcal effusion
- Due to ↑ vascular permeability & inflammation
- More common, usually transient & reversible
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