2024 McDonald Criteria: MRI and Paraclinical Updates for Multiple Sclerosis

A practical radiology review of 2024 McDonald Criteria: MRI and Paraclinical Updates for Multiple Sclerosis, focused on imaging findings, differential diagnosis, reporting...

RadPhrases Editorial TeamJuly 31, 20262 min read

Clinical workstation organizing radiology images within a tiered classification framework

A practical radiology review of 2024 McDonald Criteria: MRI and Paraclinical Updates for Multiple Sclerosis, focused on imaging findings, differential diagnosis, reporting points, and high-yield teaching pearls.

Definition

》Revised framework for diagnosing Multiple Sclerosis (MS) across all ages and clinical forms
》Emphasizes MRI and paraclinical biomarkers to increase specificity and allow earlier diagnosis
Key Diagnostic Concepts

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2024 McDonald Criteria: MRI and Paraclinical Updates for Multiple Sclerosis

Definition

Related calculators

Optic nerve (NEW 5th region)

Imaging Highlights

Central Vein Sign (CVS)

(Best with 3T or 7T MRI using T2/SWI)

Paramagnetic Rim Lesions (PRLs)

CSF Biomarkers

Oligoclonal Bands (OCB) or Kappa Free Light Chains (kFLC) interchangeable

Paediatric MS

Older Age & Comorbidities (≥50y)

Confirm with extra features

Radiologically Isolated Syndrome (RIS)

Unified Framework

Key Radiologic Takeaways

Practical Checklist

Clinical use note

Build the category and report statement together

Definition

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Continue learning

Optic nerve (NEW 5th region)

Imaging Highlights

Central Vein Sign (CVS)

(Best with 3T or 7T MRI using T2/SWI)

Paramagnetic Rim Lesions (PRLs)

CSF Biomarkers

Oligoclonal Bands (OCB) or Kappa Free Light Chains (kFLC) interchangeable

Paediatric MS

Older Age & Comorbidities (≥50y)

Confirm with extra features

Radiologically Isolated Syndrome (RIS)

Unified Framework

Key Radiologic Takeaways

Practical Checklist

Clinical use note

Build the category and report statement together